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Psychedelic Information Theory

Shamanism in the Age of Reason

References

Psychedelics and the Human Receptorome

Ray TS; PLoS One. 2010; 5(2): e9019.

Figure 1 : Twenty-five drugs assayed for this study by the NIMH-PDPS include sixteen phenylalkylamines, eight tryptamines, and one ergoline. The three control drugs are believed to be non-psychedelic.

Mol/Target5ht1a5ht1b5ht1d5ht1e5ht2a5ht2b5ht2c5ht5a5ht65ht7D1A-2AA-2BA-2C
2C-E2.913.003.542.603.764.003.380.001.932.770.002.712.913.44
2C-B2.753.113.713.053.694.003.180.002.632.810.002.642.313.12
LSD3.734.003.702.623.543.113.113.643.753.772.342.930.000.00
DOI0.002.313.002.663.443.134.000.002.341.901.673.793.132.88
DMT0.000.003.913.282.580.003.423.163.354.003.512.753.533.53
Psilocin2.882.193.403.032.144.002.522.832.822.823.371.361.571.03
5-MeO-DMT4.002.413.481.720.980.691.551.842.733.692.380.000.861.57
DiPT4.000.002.510.000.003.480.000.000.000.000.000.002.622.68
Mescaline3.610.000.003.160.003.970.000.000.000.000.002.920.004.00
MDMA0.000.000.000.000.003.640.000.000.000.000.002.943.093.21
6-F-DMT2.813.073.662.742.473.932.582.434.003.802.670.002.993.24
Lisuride4.002.270.000.002.743.010.002.992.612.640.003.223.783.88
4C-T-22.040.000.001.773.334.003.092.560.002.180.000.000.000.00

Table 1: A list of popular psychedelic drugs and receptor targets in order of 5-HT2A receptor affinity. A value of 4.00 indicates high affinity at that target; any value under 2.00 should be considered imperceptible. Non-psychedelic control molecules are listed at the bottom for comparison.3

Web Resource: www.plosone.org



Keywords: psychedelics, receptor affinity, 5-HT

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