Psychedelic Information Theory
Shamanism in the Age of Reason
Search Results : receptors
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Substances that Enhance Recall and Lucidity During Dreaming
... antagonist of presynaptic acetylcholine receptors, and allosteric modulators (such as allosterically potentiating ligands) of acetylcholine and nicotinic receptors. 6. A method according to claim 5 wherein said substances are selected fr...
... REM suppression Hallucinogens which target ACh receptors are reported to produce very vivid waking dreams and concrete hallucinations. Anticholinergics cause drowsiness, but at high doses also induce a disruptive sleep and a qualitatively unique f...
Notes on Physiological Driving of Psychedelics
... processes, but since there are 5-HT receptors distributed throughout the entire body it is certainly within the realm of possibility. ...
An Overview of Physical Shamanism
... noises to amplify modulatory interruption of 5HT receptors in the gut to drive purgation. A fast rustling or shushing noise, like a snake rattle or wind through tree branches, evokes alpha-range relaxation and mental fluidity, and may also create go...
Distribution of 5HT2A receptors in the human brain: comparison of data in vivo and post mortem
... determined distribution of 5HT2A receptors in human brains. The in vivo method seems to be sensitive enough to detect changes in receptor density of more than 18%....
... 5-HT2, 5-HT1C, and the recently described 5-HT2F receptors have been classified as members of the 5-HT2 receptor family, and they have been renamed 5-HT2A, 5-HT2C and 5-HT2B, respectively. The regional distribution and cellular localization of mRNA ...
The distribution of 5-HT1A and 5-HT2A receptor mRNA in human brain
We have examined the distribution of 5-HT1A and 5-HT2A receptor mRNAs in post-mortem human hippocampus, neocortex, raphe nuclei, cerebellum and basal ganglia using in situ hybridization histochemistry. Receptor transcripts in brains from two males an...
DOI disrupts prepulse inhibition of startle in rats via 5-HT2A receptors in the ventral pallidum.
Serotonin (5-HT)2A receptors are known to be involved in prepulse inhibition of the startle response (PPI), a measure of sensorimotor inhibition that is deficient in schizophrenia, Huntington's disease, and obsessive compulsive disorder. In the prese...
How Hallucinogens Play Their Mind-Bending Games
... Mount Sinai Hospital in New York City likens the receptors to a lock into which both hallucinogenic and nonhallucinogenic keys fit. While LSD may turn this lock to the right, kicking off one set of responses, lisuride turns the tumbler to the left, ...
An Interview with Dave Nichols
... idea that when these things bind to their brain receptors, if we could lock them into the same shape that the receptor had, their potency would increase, and that would give us some idea of what the shape was, much in the way — to use a simple an...
... they brush against neural receptor sites; if the receptors are a good fit then the crystals get stuck for a short period of time. The bonding of amine ligands to serotonin and dopamine receptors is where psychedelic action begins.1,2 Serotonin and...
... diffuse across the synaptic cleft and activate receptors on the postsynaptic neuron. The human brain has a huge number of synapses. Each of the 1011 (one hundred billion) neurons has on average 7,000 synaptic connections to other neurons. It ha...
... where 5-hydroxytryptamine2A (5-HT2A) serotonin receptors respond to the action of hallucinogens and atypical antipsychotic drugs, we have examined the cellular and subcellular distribution of these receptors in the cerebral cortex of macaque monke...
... receptor signaling. 125I-LSD binding to 5-HT2A receptors was reduced in cortical regions, demonstrating a reduction in 5-HT2A receptor density. Taken together, these results indicate that adaptive changes in LSD-stimulated serotonin receptor signa...
Rationale Serotonin (5-Hydroxytryptamine, 5-HT) receptors play an important role in perception, affect regulation and attention. Pharmacological challenge with the 5-HT2A agonist psilocybin (PY) is useful in studying the neurobiological basis of cog...
Psychedelic Information Theory
... of molecules hitting a tiny subset of neural receptors for a relatively short duration of time. The ongoing information process generated by this small pharmacological interaction goes far beyond the normal range of what we expect drugs to accom...
What is Psychedelic Information Theory?
... hallucination even though they may target unique receptors and/or destabilize consciousness in a wholly unique way. ...
Presynaptic regulation of recurrent excitation by D1 receptors in prefrontal circuits
... revealed a role for dopamine (DA) acting at D1 receptors in the modulation of a prefrontal neuron's excitatory response to its preferred stimulus (3). The sustained response of prefrontal neurons in the absence of a stimulus has generated consider...
... interpreted as vision. Most of the receptors are rods, which are found predominately in the periphery of the retina, whereas the cones are located mostly in the center and near periphery of the retina. Although there are approximately ...
Increasing evidence suggests a link between attention, working memory, serotonin (5-HT) and prefrontal cortex activity. In an attempt to tease out the relationship between these elements, this study tested the effects of the hallucinogenic 5-HT1A/2A ...
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