References

Impairment by lysergic acid diethylamide of accuracy in performance of a delayed alternation test in monkeys

Jarvik M, Chorover S; Psychopharmacology, Volume 1, Number 3 / May, 1960

Monkeys were found to show impairment in performing the delayed alternation problem following injections of LSD in initial doses as low as 0.005 mg/kg. The effect of this drug was primarily reflected in a decrease in accuracy of response, although increasingly large doses tended also to depress the rate of performance. Tolerance to the effects of LSD rapidly developed and persisted for several days, at least.

Unlike LSD, amphetamine, pentobarbital and chlorpromazine either did not produce changes in accuracy, or when they did, these changes were relatively small compared to the effects of these drugs on the pressing rate. The possibility is suggested that the partial similarity of the effects of LSD to those obtained in monkeys following bifrontal lesions may reflect the operation of some common factor.

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