Psychedelic Information Theory
Shamanism in the Age of Reason
Search Results : "apical dendrites"
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... excitatory postsynaptic currents (EPSCs) in apical dendrites of layer V pyramidal cells of prefrontal cortex; this effect was mediated by 5-HT2A receptors, a proposed site of action of hallucinogenic and atypical antipsychotic drugs. Unexpected...
... high concentrations of this receptor on the apical dendrites of pyramidal cells in layer V of the cortex may modulate cognitive processes,[5][6][7] by enhancing glutamate release followed by a complex range of interactions with the 5-HT1A,[8] G...
... excitatory postsynaptic potentials at apical dendrites of layer V cortical pyramidal cells. We propose that an effect of hallucinogens upon glutamatergic transmission in the cerebral cortex may be responsible for the higher-level cognitiv...
5-HT2A Agonism and Multisensory Binding
... Cortical layer V neurons receiving input through apical dendrites are one of the primary conduits for binding coherent sensory perception across the entire cortical surface of the brain.14 Layer V pyramidal cells are unique in that they mediate mul...
By intracellular and whole cell recording in rat brain slices, it was found that bath-applied serotonin (5-HT) produces an increase in the frequency and amplitude of spontaneous excitatory postsynaptic potentials/currents (EPSPs/EPSCs) in layer V pyr...
... creating a flood of glutamate wherever shafts of apical dendrites intersect with lateral projections from proximal neural columns.18 Glutamate flooding at lateral dendritic arbors of pyramidal neurons is the result of asynchronous glutamate release ...
... confined to their parallelly aligned proximal apical dendrites that formed two intensely stained bands above and below layer IV. In double-label experiments, 5-HT2A label was found in calbindin D28k-positive, nonphosphorylated-neurofilament-posit...
Cortical Region Interactions and the Functional Role of Apical Dendrites
The basal and distal apical dendrites ofpyramidal cells occupy distinct cortical layers and are targeted by axons originating in different cortical regions. Hence, apical and basal dendrites receive information from distinct sources. Physiological ev...
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