Psychedelic Information Theory
Shamanism in the Age of Reason
Search Results : "pyramidal cells"
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... currents (EPSCs) in apical dendrites of layer V pyramidal cells of prefrontal cortex; this effect was mediated by 5-HT2A receptors, a proposed site of action of hallucinogenic and atypical antipsychotic drugs. Unexpectedly, although the effect of 5...
... of this receptor on the apical dendrites of pyramidal cells in layer V of the cortex may modulate cognitive processes,[5][6][7] by enhancing glutamate release followed by a complex range of interactions with the 5-HT1A,[8] GABAA,[9] adenosine A...
... at apical dendrites of layer V cortical pyramidal cells. We propose that an effect of hallucinogens upon glutamatergic transmission in the cerebral cortex may be responsible for the higher-level cognitive, perceptual, and affective distorti...
5-HT2A Agonism and Multisensory Binding
... uninhibited network cross-excitability. Layer V pyramidal cells and perceptual binding In the human brain the highest density of 5-HT2A receptors are expressed on the dendrites of cortical layer V pyramidal cells3,4,5,6,8, and the highest density ...
... potentials/currents (EPSPs/EPSCs) in layer V pyramidal cells of neocortex and transitional cortex (e.g. medial prefrontal, cingulate and frontoparietal). The EPSCs were suppressed by LY293558, an antagonist selective for the AMPA subtype of exci...
... especially those expressed on neocortical pyramidal cells. Activation of 5-HT2A receptors also leads to increased cortical glutamate levels presumably by a presynaptic receptor-mediated release from thalamic afferents. These findings have led...
... various degrees, a cortical input from layer V pyramidal cells. It is also well established that all long-range corticofugal projections reaching the brainstem and spinal cord arise exclusively from layer V neurons. These observations raise the po...
... and immuno-negative pyramidal cells, suggesting that probably all pyramidal cells express 5-HT2A receptors. 5-HT2A label was also found in large- and medium-size interneurons, some of which were immuno-positive for calbi...
Cortical Region Interactions and the Functional Role of Apical Dendrites
The basal and distal apical dendrites ofpyramidal cells occupy distinct cortical layers and are targeted by axons originating in different cortical regions. Hence, apical and basal dendrites receive information from distinct sources. Physiological ev...
Presynaptic regulation of recurrent excitation by D1 receptors in prefrontal circuits
... unitary excitatory neurotransmission in layer V pyramidal cells by decreasing its reliability. These effects, which are reproduced by a selective D1 agonist and blocked by a D1 antagonist, are independent of voltage changes and are not attenuated b...
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