Psychedelic Information Theory
Shamanism in the Age of Reason
Search Results : 5-HT2A
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Activation of the mitogen-activated protein kinase pathway via the 5-HT2A receptor
... arterial smooth muscle through activation of a 5-ht2a receptor. Tyrosine kinase inhibitors including genistein and the specific MEK inhibitor PD098059, but not the inactive tyrosine kinase congener daidzein reduced and shifted 5-HT-induced contrac...
... prefrontal cortex; this effect was mediated by 5-ht2a receptors, a proposed site of action of hallucinogenic and atypical antipsychotic drugs. Unexpectedly, although the effect of 5-HT was Ca2+-dependent and tetrodotoxin-sensitive, it did not appe...
Distribution 5-ht2a is expressed widely throughout the central nervous system (CNS). It is expressed near most of the serotoninergic terminal rich areas, including neocortex (mainly prefrontal, parietal, and somatosensory cortex) and the olfactory...
5-HT2A Agonism and Multisensory Binding
... are active as full or partial agonists at the 5-ht2a receptor subtype, and all produce similar visual hallucinations that are immediately recognizable as psychedelic.1 Although the 5-HT2A receptor subtype is not the only receptor implicated in ha...
... it is believed that hallucinogens stimulate 5-ht2a receptors, especially those expressed on neocortical pyramidal cells. Activation of 5-HT2A receptors also leads to increased cortical glutamate levels presumably by a presynaptic receptor-media...
The Multi-State Theory of Psychedelic Activation...
Distribution of 5HT2A receptors in the human brain: comparison of data in vivo and post mortem
AIM: The study presented here firstly compares the distribution of the binding potential of the serotonin-5HT2A receptor as measured in vivo with data of receptor density taken from literature. Secondly, the sensitivity of the method to detect gradua...
... receptor family, and they have been renamed 5-ht2a, 5-HT2C and 5-HT2B, respectively. The regional distribution and cellular localization of mRNA coding for the members of 5-HT2 receptor family were investigated in consecutive tissue sections fr...
The distribution of 5-HT1A and 5-HT2A receptor mRNA in human brain
We have examined the distribution of 5-HT1A and 5-ht2a receptor mRNAs in post-mortem human hippocampus, neocortex, raphe nuclei, cerebellum and basal ganglia using in situ hybridization histochemistry. Receptor transcripts in brains from two males an...
DOI disrupts prepulse inhibition of startle in rats via 5-HT2A receptors in the ventral pallidum.
... In the present studies, the localization of the 5-ht2a receptors responsible for modulating PPI was investigated using central injections of the hallucinogenic 5-HT2 agonist DOI and the novel 5-HT2A antagonist MDL 100,907. 5-HT2A receptors are dens...
... the cortical sites where 5-hydroxytryptamine2A (5-ht2a) serotonin receptors respond to the action of hallucinogens and atypical antipsychotic drugs, we have examined the cellular and subcellular distribution of these receptors in the cerebral corte...
Effects of psilocybin on time perception and temporal control of behaviour in humans
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... psilocybin alone and after pretreatment with the 5-ht2a antagonist ketanserin on multiple object tracking and spatial working memory, in eight healthy human volunteers. Psilocybin significantly reduced attentional tracking ability, but had no signif...
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