Psychedelic Information Theory
Shamanism in the Age of Reason
Search Results : binding
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... aggregate of modulatory interference at sensory binding junctions? During the process of formally describing the action of these pulses, it became obvious that the pulsing interference was a carrier wave for hallucination, like the flickering frame...
... on its affinity and selective agonism in sensory binding pathways; and that the unique interrupt and ADSR envelope created by each molecule is responsible for its unique hallucinogenic patterns and multisensory signatures. The tenets of Shamanism ...
... suggest a novel mechanism wherein, upon DAMGO binding, CaM is released from the μ receptor and activates phospholipase C. Subsequently, phospholipase C generates diacylglycerides that activate PKCε. In contrast, U69,593 appears to act v...
Thalamic circuitry and thalamocortical synchrony
... of the cerebral hemisphere, could extend the binding process by providing a basis for unifying activity in the somatosensory and motor cortex during movement performance (Ribary et al. 1991; Murthy & Fetz 1992, 1996a,b; Sanes & Donoghue 1993), a...
5-HT2A Agonism and Multisensory Binding
... the recurrent circuits responsible for real-time binding of sensation to multisensory perception, affective behavior, and the process of consciousness. 5-HT2A receptor mechanics The 5-HT2A receptor is a G protein-coupled receptor (GPCR), which mea...
... have particularly high levels of local circadian binding. Usually circadian rhythms must be synched before psychic bonding between subjects can begin, though there is anecdotal evidence that psychic bonding can take place over telepresence if consta...
... Hz. Gamma rhythms are thought to represent binding of different populations of neurons together into a network for the purpose of carrying out a certain cognitive or motor function. ...
... correlate with their in vitro 5-HT2 receptor binding affinities in rat cortical homogenates. In order to ascertain if this correlation applies to human 5-HT2 receptors as well, we examined the affinities of 13 psychoactive compounds at 3H-ketans...
Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents
... derivatives, for cortical 5-HT1 and 5-HT2 binding sites were compared with two measures of behavioral activity. It was found that a significant correlation (r = 0.938) exists between the 5-HT2 binding affinities of these agents and their ED50...
... pathways responsible for multisensory binding.5 At low doses hallucinogenic interruption is felt as entoptic hallucination, but at higher doses modulatory interruption leads to more extreme frame destabilization. Subjects under the influe...
An Overview of Physical Shamanism
... (Fig. 6); this is the traditional method for binding psychedelic memory into physical space. The act of singing, drumming, or dancing also drives feedback and amplifies the energy of the psychedelic experience, thus making music the primary medi...
... can be applied to audio and tactile sensory binding; any periodic sensory interrupt within the frequency band of human consciousness will necessarily induce field-like hallucinations with stable form constants and properties related directly to...
Thalamocortical afferents in rat transiently express high-affinity serotonin uptake sites
... cortex. In the postnatal rats, [3H]citalopram binding sites were densely distributed in the lower portion of layer III, lamina IV, and upper layer V in the primary visual, somatosensory, and auditory cortices. In the primary somatosensory cortex,...
Distribution of 5HT2A receptors in the human brain: comparison of data in vivo and post mortem
... here firstly compares the distribution of the binding potential of the serotonin-5HT2A receptor as measured in vivo with data of receptor density taken from literature. Secondly, the sensitivity of the method to detect gradual differences in rece...
... in good agreement with that of the corresponding binding sites, although discrepancies were sometimes observed. 5-HT2C (formerly 5-HT1C) mRNA was present at very high levels in the choroid plexuses. However, very high levels were also seen in many o...
... conformation of phenethylamine ligands upon binding to the 5-HT(2A) receptor. These benzocycloalkane analogues were assayed for their receptor binding affinity and ability to activate downstream signaling pathways, and one exceptional compound ...
An Interview with Dave Nichols
... we have, in the animal models and the receptor binding assays, those are the most potent drugs in binding to these particular types of brain receptors that have ever been discovered. Are they more potent than LSD, which was the so-far unmatched...
... pathways. Breadth of Psychedelic Receptor binding Mol/Target5ht1a5ht1b5ht1d5ht1e5ht2a5ht2b5ht2c5ht5a5ht65ht7D1A-2AA-2BA-2C2C-E2.913.003.542.603.764.003.380.001.932.770.002.712.913.442C-B2.753.113.713.053.694.003.180.002.632.810.002.642.313....
... LSD treatment, LSD-stimulated [35S]GTPgammaS binding, an index of G-protein coupling, was measured in the rat brain by autoradiography. After chronic LSD, a significant reduction in LSD-stimulated [35S]GTPgammaS binding was observed in the media...
Notes on Sensory Binding and Coherence
The so-called "binding problem" of cognitive science is approached from a variety of angles, but all of them rely on measuring the strength, frequency, synchrony, and resonance of spike waves propagating through neural assemblies. There are many ways...
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