Psychedelic Information Theory
Shamanism in the Age of Reason
Search Results : receptors
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Reviews for Psychedelic Information Theory
... action of psychedelics (mostly around 5-HT receptors, since that's where research exists) is to destabilize neural network switching related to serotonergic and cholinergic visual processing, as well as the auditory, olfactory, and tactile sen...
... the need to study endogenously expressed receptors in appropriate model systems becomes increasingly important. Here we examine signal transduction mechanisms mediated by endogenous κ-opioid receptors in C6 glioma cells, an astrocytic m...
Acute μ and κ opioids activate the ERK/MAPK phosphorylation cascade that represents an integral part of the signaling pathway of growth factors in astrocytes. By this cross-talk, opioids may impact neural development and plasticity among ot...
Role of GABAB receptor-mediated inhibition in reciprocal interareal pathways of rat visual cortex
... by gamma-aminobutyric acid-A (GABAA) and GABAB receptors. By using intracellular and patch-clamp recordings in slices of rat visual cortex we studied the balance of excitation and inhibition in different intracortical pathways. The study was focus...
Serotonin research: contributions to understanding psychoses
... drugs that function as agonists at serotonin-2A receptors. The fundamental idea that psychotic states seen in psychiatric disorders such as schizophrenia might be attributable, in part, to abnormalities in serotonergic systems began with the almost...
Thalamic circuitry and thalamocortical synchrony
... acid (AMPA) subunit composition of receptors at synapses formed by branches of the same corticothalamic axon in the RTN and dorsal thalamus are an important element in the capacity of the cortex to synchronize low-frequency oscillation...
... cortex; this effect was mediated by 5-HT2A receptors, a proposed site of action of hallucinogenic and atypical antipsychotic drugs. Unexpectedly, although the effect of 5-HT was Ca2+-dependent and tetrodotoxin-sensitive, it did not appear to i...
Functional selectivity and classical concepts of quantitative pharmacology
... of various agonists activating only the 5-HT2A receptors were shown to differ (Gonzalez-Maeso et al., 2003). However, at present, there is no clear evidence to suggest what structural characteristics of a ligand promote the activation of one effec...
Serotonin and brain: evolution, neuroplasticity, and homeostasis
... that have specialized actions through specific receptors on the membrane potential of postsynaptic neurons. However, these chemicals have more complex functions both within the neuron and on its varied cellular targets. These functions include ...
... AMPA,[11] mGluR2/3,[12] mGlu5,[13] and OX2 receptors.[14][15] In the rat cerebellum, the protein has also been found in the Golgi cells of the granular layer,[16] and in the Purkinje cells.[17][18] In the periphery, it is highly expressed i...
... as partial agonists at 5-HT2A and other 5-HT2 receptors in the central nervous system. The noradrenergic locus coeruleus and the cerebral cortex are among the regions where hallucinogens have prominent effects through their actions upon a 5-HT2A ...
5-HT2A Agonism and Multisensory Binding
... of classical psychedelic interaction. 5-HT2A receptors are ubiquitous throughout the nervous system, found in the sensory cortex, the frontal cortex, the olfactory cortex, the basal ganglia, the cerebellum, the hippocampus, thalamic nuclei, brai...
... amplitudes. These data suggest 5-HT, via 5-HT2A receptors, enhances spontaneous EPSPs/EPSCs in neocortical layer V pyramidal cells through a TTX-sensitive focal action in the apical dendritic field which may involve both pre- and postsynaptic mecha...
... is believed that hallucinogens stimulate 5-HT2A receptors, especially those expressed on neocortical pyramidal cells. Activation of 5-HT2A receptors also leads to increased cortical glutamate levels presumably by a presynaptic receptor-mediated rel...
... We have now discovered that activation of 5-HT2A receptors in primary aortic smooth muscle cells provides a previously unknown and extremely potent inhibition of tumor necrosis factor (TNF)-α-mediated inflammation. 5-HT2A receptor stimulation ...
5HT2-receptors and serotonin release: Their role in human platelet aggregation
Involvement of 5HT2 receptors in human platelet aggregation was assessed by studying the effect of ADP, epinephrine and thrombin on 3H-5HT release from platelets. The release experiments were made with a perfusion method to preserve any compound, rel...
... Through the mechanistic means of pheromones and receptors insects can coalesce into a hive mind capable of many coordinated tasks; this is non-verbal cooperation based solely on encoded rules of instinctive behavior. Fish form schools, birds form f...
Physical Shamanism and Shamanic Therapy
... is because the psychedelic must interrupt 5-HT receptors in the gut as well as the brain before metabolic homeostasis can be fully uncoupled and re-tuned. Techniques of dieting and fasting merely speed and amplify the overall destabilizing effect ...
The Case Against the Spirit Model of Psychedelic Action
... power to a chemical that naturally bonds to receptors in your visual cortex, it demonstrates a fundamental misunderstanding of how neurochemical stimulation results in direct perception. The visions are the result of the molecule interacting wi...
... if this correlation applies to human 5-HT2 receptors as well, we examined the affinities of 13 psychoactive compounds at 3H-ketanserin-labelled 5-HT2 receptors in human cortical samples. Both radioligand binding and autoradiographical procedur...
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