Psychedelic Information Theory
Shamanism in the Age of Reason
Search Results : serotonin
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... aminergic system of perception, modulated by serotonin and dopamine. This complex interference pattern is what I am describing with the Control Interrupt Model of psychedelic action. According to PIT, each hallucinogen creates a slightly differe...
... of hallucinogens are thought to be mediated by serotonin receptor activation; however, how these drugs elicit the unusual behavioral effects remains largely a mystery, despite much research. We have undertaken the first comprehensive analysis of g...
Serotonin research: contributions to understanding psychoses
The history of serotonin research is closely related to the study of hallucinogenic drugs that function as agonists at serotonin-2A receptors. The fundamental idea that psychotic states seen in psychiatric disorders such as schizophrenia might be att...
A systems model of altered consciousness: integrating natural and drug-induced psychoses
... glutamate receptor antagonist, ketamine, and the serotonin-2A (5-HT(2A)) receptor agonist, psilocybin, suggest that the hallucinogenic effects of these drugs arise, at least in part, from their common capacity to disrupt thalamo-cortical gating of e...
Previously, serotonin (5-HT) was found to induce a marked increase in glutamatergic spontaneous excitatory postsynaptic currents (EPSCs) in apical dendrites of layer V pyramidal cells of prefrontal cortex; this effect was mediated by 5-HT2A receptors...
Functional selectivity and classical concepts of quantitative pharmacology
... illustrating this phenomenon are presented from serotonin, opioid, dopamine, vasopressin, and adrenergic receptor systems. A variety of mechanisms may influence this apparently ubiquitous phenomenon. It may be initiated by differences in ligand-ind...
Serotonin and brain: evolution, neuroplasticity, and homeostasis
... consequences on the plasticity of the neurons. serotonin is an ancient chemical synthesized from an indole-containing precursor, tryptophan. A review of the evolution of this chemical within biological systems helps appreciate its holistic actio...
This brief review traces the serotonin (5-HT) hypothesis of the action of hallucinogenic drugs from the early 1950s to the present day. There is now converging evidence from biochemical, electrophysiological, and behavioral studies that the two major...
... rat brain slices, it was found that bath-applied serotonin (5-HT) produces an increase in the frequency and amplitude of spontaneous excitatory postsynaptic potentials/currents (EPSPs/EPSCs) in layer V pyramidal cells of neocortex and transitional c...
... the virtually contemporaneous discovery of both serotonin (5-HT) and lysergic acid diethylamide (LSD-25), early brain research focused intensely on the possibility that LSD or other hallucinogens had a serotonergic basis of action and reinforced th...
The G protein-coupled serotonin 5-hydroxytryptamine (5-HT)2A receptor is primarily recognized for its role in brain neurotransmission, where it mediates a wide variety of functions, including certain aspects of cognition. However, there is significan...
5HT2-receptors and serotonin release: Their role in human platelet aggregation
... important in those pathological states in which serotonin, released by activated platelets, may increase aggregation....
Physical Shamanism and Shamanic Therapy
... organization. For instance, 5-HT2A receptors and serotonin release have been shown to play a large role in mediating blood platelet aggregation.10 Hallucinogens target 5-HT2A receptors, and platelet aggregation is a fundamental immune mechanism. 5-H...
... occurs along with a proportional decrease in serotonin, norepinephrine, and aminergic activity in the pre-frontal cortex (PFC). The interplay between these two systems acts like a tide between waking and sleeping worlds. Drugs which increase ami...
Presynaptic uptake blockade hypothesis for LSD action at the lateral inhibitory synapse in Limulus
... of the optic nerve in the presence of LSD, serotonin (5-HT), chlorimipramine, or a bathing medium whose high Mg++ and low Ca++ concentrations partially or completely blocked synaptic transmission. We found (a) light-evoked and antidromically s...
Thalamocortical afferents in rat transiently express high-affinity serotonin uptake sites
... to delineate the distribution of high-affinity serotonin (5-HT) uptake sites in the cerebral cortex. In the postnatal rats, [3H]citalopram binding sites were densely distributed in the lower portion of layer III, lamina IV, and upper layer V in th...
Distribution of 5HT2A receptors in the human brain: comparison of data in vivo and post mortem
... the distribution of the binding potential of the serotonin-5HT2A receptor as measured in vivo with data of receptor density taken from literature. Secondly, the sensitivity of the method to detect gradual differences in receptor densities is evaluat...
Because of their similarities, serotonin 5-HT2, 5-HT1C, and the recently described 5-HT2F receptors have been classified as members of the 5-HT2 receptor family, and they have been renamed 5-HT2A, 5-HT2C and 5-HT2B, respectively. The regional distrib...
DOI disrupts prepulse inhibition of startle in rats via 5-HT2A receptors in the ventral pallidum.
serotonin (5-HT)2A receptors are known to be involved in prepulse inhibition of the startle response (PPI), a measure of sensorimotor inhibition that is deficient in schizophrenia, Huntington's disease, and obsessive compulsive disorder. In the prese...
How Hallucinogens Play Their Mind-Bending Games
... the debate. While Roth concedes that cortical serotonin 2A receptors are likely part of the mechanism of hallucinogenic drugs, Dave Nichols, a molecular pharmacologist at Purdue University, believes the thalamus must be involved in some manner. "...
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