Psychedelic Information Theory
Shamanism in the Age of Reason
References
Psychedelics and the Human Receptorome
Ray TS; PLoS One. 2010; 5(2): e9019.
Figure 1 : Twenty-five drugs assayed for this study by the NIMH-PDPS include sixteen phenylalkylamines, eight tryptamines, and one ergoline. The three control drugs are believed to be non-psychedelic.
| Mol/Target | 5ht1a | 5ht1b | 5ht1d | 5ht1e | 5ht2a | 5ht2b | 5ht2c | 5ht5a | 5ht6 | 5ht7 | D1 | A-2A | A-2B | A-2C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2C-E | 2.91 | 3.00 | 3.54 | 2.60 | 3.76 | 4.00 | 3.38 | 0.00 | 1.93 | 2.77 | 0.00 | 2.71 | 2.91 | 3.44 |
| 2C-B | 2.75 | 3.11 | 3.71 | 3.05 | 3.69 | 4.00 | 3.18 | 0.00 | 2.63 | 2.81 | 0.00 | 2.64 | 2.31 | 3.12 |
| LSD | 3.73 | 4.00 | 3.70 | 2.62 | 3.54 | 3.11 | 3.11 | 3.64 | 3.75 | 3.77 | 2.34 | 2.93 | 0.00 | 0.00 |
| DOI | 0.00 | 2.31 | 3.00 | 2.66 | 3.44 | 3.13 | 4.00 | 0.00 | 2.34 | 1.90 | 1.67 | 3.79 | 3.13 | 2.88 |
| DMT | 0.00 | 0.00 | 3.91 | 3.28 | 2.58 | 0.00 | 3.42 | 3.16 | 3.35 | 4.00 | 3.51 | 2.75 | 3.53 | 3.53 |
| Psilocin | 2.88 | 2.19 | 3.40 | 3.03 | 2.14 | 4.00 | 2.52 | 2.83 | 2.82 | 2.82 | 3.37 | 1.36 | 1.57 | 1.03 |
| 5-MeO-DMT | 4.00 | 2.41 | 3.48 | 1.72 | 0.98 | 0.69 | 1.55 | 1.84 | 2.73 | 3.69 | 2.38 | 0.00 | 0.86 | 1.57 |
| DiPT | 4.00 | 0.00 | 2.51 | 0.00 | 0.00 | 3.48 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.62 | 2.68 |
| Mescaline | 3.61 | 0.00 | 0.00 | 3.16 | 0.00 | 3.97 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.92 | 0.00 | 4.00 |
| MDMA | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.94 | 3.09 | 3.21 |
| 6-F-DMT | 2.81 | 3.07 | 3.66 | 2.74 | 2.47 | 3.93 | 2.58 | 2.43 | 4.00 | 3.80 | 2.67 | 0.00 | 2.99 | 3.24 |
| Lisuride | 4.00 | 2.27 | 0.00 | 0.00 | 2.74 | 3.01 | 0.00 | 2.99 | 2.61 | 2.64 | 0.00 | 3.22 | 3.78 | 3.88 |
| 4C-T-2 | 2.04 | 0.00 | 0.00 | 1.77 | 3.33 | 4.00 | 3.09 | 2.56 | 0.00 | 2.18 | 0.00 | 0.00 | 0.00 | 0.00 |
Table 1: A list of popular psychedelic drugs and receptor targets in order of 5-HT2A receptor affinity. A value of 4.00 indicates high affinity at that target; any value under 2.00 should be considered imperceptible. Non-psychedelic control molecules are listed at the bottom for comparison.3
Web Resource: www.plosone.org
Keywords: psychedelics, receptor affinity, 5-HT
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