Psychedelic Information Theory
Shamanism in the Age of Reason
Search Results : 5-HT
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Activation of the mitogen-activated protein kinase pathway via the 5-HT2A receptor
... our laboratory has tested the hypothesis that 5-ht can activate the MAPK pathway in arterial smooth muscle through activation of a 5-HT2A receptor. Tyrosine kinase inhibitors including genistein and the specific MEK inhibitor PD098059, but not th...
Previously, serotonin (5-ht) was found to induce a marked increase in glutamatergic spontaneous excitatory postsynaptic currents (EPSCs) in apical dendrites of layer V pyramidal cells of prefrontal cortex; this effect was mediated by 5-HT2A receptors...
Distribution 5-ht2A is expressed widely throughout the central nervous system (CNS). It is expressed near most of the serotoninergic terminal rich areas, including neocortex (mainly prefrontal, parietal, and somatosensory cortex) and the olfactory...
5-HT2A Agonism and Multisensory Binding
... are active as full or partial agonists at the 5-ht2A receptor subtype, and all produce similar visual hallucinations that are immediately recognizable as psychedelic.1 Although the 5-HT2A receptor subtype is not the only receptor implicated in ha...
... it was found that bath-applied serotonin (5-ht) produces an increase in the frequency and amplitude of spontaneous excitatory postsynaptic potentials/currents (EPSPs/EPSCs) in layer V pyramidal cells of neocortex and transitional cortex (e.g....
... contemporaneous discovery of both serotonin (5-ht) and lysergic acid diethylamide (LSD-25), early brain research focused intensely on the possibility that LSD or other hallucinogens had a serotonergic basis of action and reinforced the idea that...
The Multi-State Theory of Psychedelic Activation...
... strongly correlate with their in vitro 5-ht2 receptor binding affinities in rat cortical homogenates. In order to ascertain if this correlation applies to human 5-HT2 receptors as well, we examined the affinities of 13 psychoactive compoun...
Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents
... of phenalkylamine derivatives, for cortical 5-ht1 and 5-HT2 binding sites were compared with two measures of behavioral activity. It was found that a significant correlation (r = 0.938) exists between the 5-HT2 binding affinities of these agent...
Psychedelics and the Human Receptorome
... drugs and receptor targets in order of 5-ht2A receptor affinity. A value of 4.00 indicates high affinity at that target; any value under 2.00 should be considered imperceptible. Non-psychedelic control molecules are listed at the bottom fo...
Distribution of 5HT2A receptors in the human brain: comparison of data in vivo and post mortem
AIM: The study presented here firstly compares the distribution of the binding potential of the serotonin-5HT2A receptor as measured in vivo with data of receptor density taken from literature. Secondly, the sensitivity of the method to detect gradua...
Because of their similarities, serotonin 5-ht2, 5-HT1C, and the recently described 5-HT2F receptors have been classified as members of the 5-HT2 receptor family, and they have been renamed 5-HT2A, 5-HT2C and 5-HT2B, respectively. The regional distrib...
The distribution of 5-HT1A and 5-HT2A receptor mRNA in human brain
We have examined the distribution of 5-ht1A and 5-HT2A receptor mRNAs in post-mortem human hippocampus, neocortex, raphe nuclei, cerebellum and basal ganglia using in situ hybridization histochemistry. Receptor transcripts in brains from two males an...
DOI disrupts prepulse inhibition of startle in rats via 5-HT2A receptors in the ventral pallidum.
Serotonin (5-ht)2A receptors are known to be involved in prepulse inhibition of the startle response (PPI), a measure of sensorimotor inhibition that is deficient in schizophrenia, Huntington's disease, and obsessive compulsive disorder. In the prese...
... the cortical sites where 5-hydroxytryptamine2A (5-ht2A) serotonin receptors respond to the action of hallucinogens and atypical antipsychotic drugs, we have examined the cellular and subcellular distribution of these receptors in the cerebral corte...
Effects of psilocybin on time perception and temporal control of behaviour in humans
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... between attention, working memory, serotonin (5-ht) and prefrontal cortex activity. In an attempt to tease out the relationship between these elements, this study tested the effects of the hallucinogenic 5-HT1A/2A receptor agonist psilocybin alon...
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